Mutations in the human PURA gene cause the neurodevelopmental PURA syndrome.In contrast to several other monogenetic disorders, almost all Candle reported mutations in this nucleic acid-binding protein result in the full disease penetrance.In this study, we observed that patient mutations across PURA impair its previously reported co-localization w

Determination of ballistic performance of Skillets an armor solution is a complicated task and evolved significantly with the application of finite element methods (FEM) in this research field.The traditional armor design studies performed with FEM requires sophisticated procedures and intensive computational effort, therefore simpler and accurate

ABSTRACT Candida auris has emerged as an outbreak pathogen associated with high mortality.Biofilm formation and linked drug resistance are common among Candida species.Drug sequestration by the biofilm matrix accounts for much of the antifungal tolerance.In this study, we examine the biofilm matrix composition and function for a diverse set of C.au

The North Atlantic copepods Calanus finmarchicus and C.helgolandicus are moving north in response to rising temperatures.Understanding the drivers of their relative geographic distributions is required in order to anticipate future changes.To explore this, we created a new spatially explicit stage-structured model of their populations throughout th

Abstract Background The evolution of the brain and its major neuropils in Panarthropoda (comprising Arthropoda, Tardigrada and Onychophora) remains enigmatic.As one of the closest relatives of arthropods, onychophorans are regarded as indispensable for a broad understanding of the evolution of panarthropod organ systems, including the brain, whose